Thursday, 30 March 2017
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Char-Broil TRU-Infrared Patio Bistro Electric Grill - $79.99

Added: 26.03.2017 9:02 | 0 views | 0 comments

Woot offers Char-Broil TRU-Infrared Patio Bistro Electric Grill, Red for $79.99. ...


[Policy Forum] A roadmap for rapid decarbonization

Added: 26.03.2017 8:26 | 0 views | 0 comments

Although the Paris Agreement's goals (1) are aligned with science (2) and can, in principle, be technically and economically achieved (3), alarming inconsistencies remain between science-based targets and national commitments. Despite progress during the 2016 Marrakech climate negotiations, long-term goals can be trumped by political short-termism. Following the Agreement, which became international law earlier than expected, several countries published mid-century decarbonization strategies, with more due soon. Model-based decarbonization assessments (4) and scenarios often struggle to capture transformative change and the dynamics associated with it: disruption, innovation, and nonlinear change in human behavior. For example, in just 2 years, China's coal use swung from 3.7% growth in 2013 to a decline of 3.7% in 2015 (5). To harness these dynamics and to calibrate for short-term realpolitik, we propose framing the decarbonization challenge in terms of a global decadal roadmap based on a simple heuristic—a “carbon law”—of halving gross anthropogenic carbon-dioxide (CO2) emissions every decade. Complemented by immediately instigated, scalable carbon removal and efforts to ramp down land-use CO2 emissions, this can lead to net-zero emissions around mid-century, a path necessary to limit warming to well below 2°C. Authors: Johan Rockström, Owen Gaffney, Joeri Rogelj, Malte Meinshausen, Nebojsa Nakicenovic, Hans Joachim Schellnhuber

[Letter] Patent pools for CRISPR technology

Added: 26.03.2017 8:26 | 0 views | 0 comments

Author: Lawrence Horn


[Letter] Patent pools for CRISPR technology—Response

Added: 26.03.2017 8:26 | 0 views | 0 comments

Authors: Jorge L. Contreras, Jacob S. Sherkow


[Report] Extremely efficient internal exciton dissociation through edge states in layered 2D perovskites

Added: 26.03.2017 8:26 | 0 views | 0 comments

Understanding and controlling charge and energy flow in state-of-the-art semiconductor quantum wells has enabled high-efficiency optoelectronic devices. Two-dimensional (2D) Ruddlesden-Popper perovskites are solution-processed quantum wells wherein the band gap can be tuned by varying the perovskite-layer thickness, which modulates the effective electron-hole confinement. We report that, counterintuitive to classical quantum-confined systems where photogenerated electrons and holes are strongly bound by Coulomb interactions or excitons, the photophysics of thin films made of Ruddlesden-Popper perovskites with a thickness exceeding two perovskite-crystal units (>1.3 nanometers) is dominated by lower-energy states associated with the local intrinsic electronic structure of the edges of the perovskite layers. These states provide a direct pathway for dissociating excitons into longer-lived free carriers that substantially improve the performance of optoelectronic devices. Authors: J.-C. Blancon, H. Tsai, W. Nie, C. C. Stoumpos, L. Pedesseau, C. Katan, M. Kepenekian, C. M. M. Soe, K. Appavoo, M. Y. Sfeir, S. Tretiak, P. M. Ajayan, M. G. Kanatzidis, J. Even, J. J. Crochet, A. D. Mohite

[Report] PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D

Added: 26.03.2017 8:26 | 0 views | 0 comments

Activating mutations in PIK3CA, the gene encoding phosphoinositide-(3)-kinase α (PI3Kα), are frequently found in estrogen receptor (ER)–positive breast cancer. PI3Kα inhibitors, now in late-stage clinical development, elicit a robust compensatory increase in ER-dependent transcription that limits therapeutic efficacy. We investigated the chromatin-based mechanisms leading to the activation of ER upon PI3Kα inhibition. We found that PI3Kα inhibition mediates an open chromatin state at the ER target loci in breast cancer models and clinical samples. KMT2D, a histone H3 lysine 4 methyltransferase, is required for FOXA1, PBX1, and ER recruitment and activation. AKT binds and phosphorylates KMT2D, attenuating methyltransferase activity and ER function, whereas PI3Kα inhibition enhances KMT2D activity. These findings uncover a mechanism that controls the activation of ER by the posttranslational modification of epigenetic regulators, providing a rationale for epigenetic therapy in ER-positive breast cancer. Authors: Eneda Toska, Hatice U. Osmanbeyoglu, Pau Castel, Carmen Chan, Ronald C. Hendrickson, Moshe Elkabets, Maura N. Dickler, Maurizio Scaltriti, Christina S. Leslie, Scott A. Armstrong, José Baselga

UPDATE 2-Cricket-Test Series New Zealand v South Africa scoreboard

Added: 26.03.2017 6:41 | 0 views | 0 comments

March 26 (Gracenote) - Scoreboard at stumps on the second day in the third and final Test between New Zealand and South Africa on Sunday in Hamilton, New Zealand South Africa 1st innings (Overnight: 123-4) D. Elgar b de Grandhomme 5 T. de Bruyn c Latham b Henry 0 H. Amla b de Grandhomme 50 J. Duminy c Patel b Henry 20 F. du Plessis c Latham b Santner

Republicans plot path forward after health care bill failure

Added: 26.03.2017 4:35 | 0 views | 0 comments

Trump setting his sights on reforming tax code, which will be more difficult given failure of GOP's Obamacare replacement

Save Up to 300 off on Select Patio Furniture at Sam’s Club - $1799.98

Added: 26.03.2017 2:09 | 0 views | 0 comments

Sam's Club offers up to 300 off on Select Patio Furniture. ...


Get 72% off NordVPN Virtual Private Network Service For a Limited Time - Deal Alert

Added: 26.03.2017 0:37 | 0 views | 0 comments

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