Thursday, 30 March 2017
News with tag Michael  RSS
[Report] A conserved NAD+ binding pocket that regulates protein-protein interactions during aging

Added: 26.03.2017 8:26 | 0 views | 0 comments

DNA repair is essential for life, yet its efficiency declines with age for reasons that are unclear. Numerous proteins possess Nudix homology domains (NHDs) that have no known function. We show that NHDs are NAD+ (oxidized form of nicotinamide adenine dinucleotide) binding domains that regulate protein-protein interactions. The binding of NAD+ to the NHD domain of DBC1 (deleted in breast cancer 1) prevents it from inhibiting PARP1 [poly(adenosine diphosphate–ribose) polymerase], a critical DNA repair protein. As mice age and NAD+ concentrations decline, DBC1 is increasingly bound to PARP1, causing DNA damage to accumulate, a process rapidly reversed by restoring the abundance of NAD+. Thus, NAD+ directly regulates protein-protein interactions, the modulation of which may protect against cancer, radiation, and aging. Authors: Jun Li, Michael S. Bonkowski, Sébastien Moniot, Dapeng Zhang, Basil P. Hubbard, Alvin J. Y. Ling, Luis A. Rajman, Bo Qin, Zhenkun Lou, Vera Gorbunova, L. Aravind, Clemens Steegborn, David A. Sinclair

WWE Asked Shawn Michaels To Wrestle AJ Styles At Wrestlemania 33

Added: 26.03.2017 0:28 | 2 views | 0 comments

Shawn Michaels has not wrestled since losing a "Career versus Streak" match against The Undertaker at WrestleMania XXVI in 2010.


Former CIA director: Flynn discussed handing Erdogan foe back to Turkey

Added: 25.03.2017 13:01 | 0 views | 0 comments

Former Central Intelligence Agency Director James Woolsey told CNN Friday that former Trump National Security Adviser Michael Flynn met with representatives of the Turkish government in 2016, and the meeting included discussion of potential ways to send a foe of Turkey's president back to face charges in that country,

Trump's ex-national security adviser 'discussed Gulen removal'

Added: 25.03.2017 9:58 | 0 views | 0 comments

Ex-national security adviser Michael Flynn met Turkish officials during the election campaign.

Michael D'Antonio: Trump now looks incompetent

Added: 25.03.2017 2:30 | 0 views | 0 comments

A President who admires strongmen tried to strong-arm the Republicans who control the United States House of Representatives. Pass the repeal of Obamacare and replace it with Trumpcare, Donald Trump told the 247 Republicans, or else you'll be ousted in a primary.

What Michael Shannon Looks Like as Cable in Deadpool 2

Added: 25.03.2017 0:36 | 0 views | 0 comments

Artist Boss Logic debuts new fan art depicting Michael Shannon as Cable in Deadpool 2.


African budget carrier Fastjet appoints new finance head

Added: 24.03.2017 8:08 | 0 views | 0 comments

March 24 (Reuters) - African budget airline Fastjet Plc said on Friday it had appointed Michael Muller, who has worked in the airlines industry for a decade and held roles at South African Airways, as its next chief financial officer.

Lawmakers demand information on Flynn's Russia ties

Added: 24.03.2017 3:15 | 1 views | 0 comments

Washington (CNN)Republicans and Democrats are demanding formation about connections between President Donald Trump's former national security adviser Michael Flynn and several foreign entities -- including the Kremlin-backed media outlet RT. Their calls come after months of controversy surrounding one of Trump's longtime campaign advisers and top aide on security matters. Questions have swirled about the nature of his ties to Russia and whether he violated any restrictions on contacts with foreign officials. The top Democrat and Republican on the House Oversight Committee sent individual letters to four top Trump administration officials requesting any documents they have related to...

O'Reilly's failed drug test cast doubt over all we've done - O'Neill

Added: 24.03.2017 2:30 | 1 views | 0 comments

Darren O'Neill believes Michael O'Reilly's positive doping test has called Irish amateur boxing's achievements into question.


Taylor hoping to follow Conlan's path with Stateside bout

Added: 24.03.2017 2:30 | 0 views | 0 comments

Katie Taylor is itching to make her US ring debut this summer after watching Michael Conlan take over New York last weekend.

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